Well I had a 95 Jeep Grand Cherokee. And what I had to do was Bi-pass the installed amp and re-wire the speakers off the leads for the deck. So I am telling you that I would let someone that is knowlegdeable in this application. I cut some wires that I shouldn't have, and fucked up some sensors. So I am saying that you need to know what you are doing. When I was finished, everything was okay, I ended up going with 3 1/2 in the dash (which was a fucking bitch let me tell you) 5 1/4 Kicks panel speakers(I had to buy the kick panels), 2 6 1/2 in the front, 6 1/2 in the back, and 2-12 in subs. I never metered it, but I shook the rear view mirror off and left a nice hole. So the question is yes you can do it, but I can not tell you what I did. I belive that there is an after market wiring harness that goes to the amp. But I just went the easier route. But I did 2 amps, and a 12 disc CD changer uner the back seats.
Oh yeah to answer your question, I had to re-drill a new hole, those vehicles just don't have the boots like some other cars, I went with some 1/0 gauge cable, I think that there is a place on the right side (looking at the engine) that you might be able to punch through if you are going with 4 gauge.