I you are taling about spoked wheels than no it don't mess up balanceing.
If your talking about alloys and spinner wheel kits than yes it does mess up the balanceing of the wheel. It is basically impossible to balance any of them. If the spin kit sits directly on the rim itself then you may have a chance. The only ones that are able to be balanced like regular are the full wheel combos such as Davin, Foose, DUB and ones like them.
i stand corrected i took mine off and there was a diffencr a real small shake was there befors so i guess it does mess up balance....i got blade spiinners on spokes so i guess it did make a difference..